1136Surveillance of Acute Flaccid Paralysis (AFP) in the Republic of Korea during 2012-2013

Background. Acute flaccid paralysis (AFP) is described as sudden onset of flaccid paralysis in one or more limbs in children and mainly caused by polioviruses. AFP surveillance was managed by World Health Organization (WHO) for standard progress of poliomyelitis eradication. Methods. This study aimed to investigate clinical and etiological characterization of paralysis cases through a nationwide AFP surveillance during 2012-2013. The AFP surveillance was conducted through reporting and laboratory testing according to the WHO recommendations. Results. In total of 178 case of AFP between 2012 and 2013, none of case was confirmed poliomyelitis. The non-polio AFP rate were 1.24 in 2012 and 1.11 in 2013 (nonpolio AFP cases/100,000 children <15years, respectively). The patients aged < 5 years accounted for the largest proportion (69.1%) of the cases. The analysis of the temporal distribution showed that occurrences were distributed randomly throughout the year, with the highest occurrence from May to July (73 cases; 41.0%). The major clinical manifestation of AFP was meningoencephalitis (71 cases; 39.9%) and the GuillainBarré Syndrome (22 cases; 12.4%). Non-polio enterovirus (NPEV) infection was diagnosed in 81 patients (45.5%), the major genotype was EV 71 (55 cases; 67.9%). In addition, present study demonstrated that while patients with AFP are not infected with wild poilovirus, they are highly positive for EV. Conclusion. The AFP surveillance systems comply with WHO-specified epidemiological and laboratory performance standards. Therefore this surveillance was important report for our knowledge of epidemic characteristics, clinical symptom associated with AFP in Korea. Disclosures. Y. S. Yoon, Korea Centers for Diseases Control and Prevention: Member, Educational support H. Kim, Korea Centers for Diseases Control and Prevention: Employee, Educational support S. W. Lee, Korea Centers for Diseases Control and Prevention: Member, Educational support J. Y. Hyeon, Korea Centers for Diseases Control and Prevention: Member, Educational support